Nature runes require level 44 RuneCrafting to make. The nature temple is found in Karamja, just north of Shilo Village. For modern magic, nature runes are used in binding spells, Alchemy, Superheat item, and Bones to Bananas. Nature runes are dropped by Ice Warriors/ Giants, Elves, Iron Dragons, et al. Nature runes spawn on an island in level 43 wilderness.